ABT-724 (hydrochloride)

ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Galphaqo5. It is selective for dopamine D4 over D2 receptors at 10 µM. ABT-724 (0.03 µmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).Formal Name: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride. CAS Number: 587870-77-7. Molecular Formula: C17H19N5 . 3HCl. Formula Weight: 402.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. lambdamax: 245, 270, 276, 317 nm. SMILES: C12=CC=CC=C1NC(CN3CCN(C4=NC=CC=C4)CC3)=N2.Cl.Cl.Cl. InChi Code: InChI=1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17,,,/h1-8H,9-13H2,(H,19,20),3*1H. InChi Key: AZFUVPBLKQGSRI-UHFFFAOYSA-N.