Zu "K04147" wurden 38 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
FAUC-213
Artikelnummer: Cay42322-1
A dopamine D4 receptor antagonist (Ki = 2.2 nM), selective for dopamine D4 receptors over dopamine D2L, D2S, and D3 receptors (Kis = 3,400, 6,300, and 5,300 nM, respectively), reduces amphetamine-induced hyperactivity in rats 7.5, 15, and 30 mg/kg. Formulation: A solid. InChI:...
| Schlagworte: | 2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-pyrazolo[1,5-a]pyridine |
| Anwendung: | Dopamine D4 receptor antagonist |
| CAS | 337972-47-1 |
| MW: | 326.82 D |
ab 68,00 €
Olanzapine
Artikelnummer: LKT-O4400.1
Olanzapine is an atypical antipsychotic. Olanzapine had high affinity for dopamine D1, D2, D4, serotonin (5HT)2A, 5HT2C, 5HT3, alpha 1-adrenergic, histamine H1, and five muscarinic receptor subtypes.
| Schlagworte: | 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| CAS | 132539-06-1 |
| MW: | 312.43 D |
ab 141,00 €
(S)-Pramipexole (hydrochloride)
Artikelnummer: Cay11981-5
(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPgammaS binding assay). It is also a partial agonist of alpha2A-adrenergic receptors (alpha2A-ARs, EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors...
| Schlagworte: | (-)-Pramipexole, (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride |
| Anwendung: | Galphai agonist |
| CAS | 104632-25-9 |
| MW: | 284.2 D |
ab 49,00 €
N,N-Dipropyldopamine (hydrobromide)
Artikelnummer: Cay28937-5
N,N-Dipropyldopamine is a dopamine receptor agonist. It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 µmol/kg, respectively), as well as reduces homovanillic acid (HVA, Cay-27307) levels in rat striatum when administered at a dose of 80...
| Schlagworte: | 4-[2-(dipropylamino)ethyl]-1,2-benzenediol, monohydrobromide |
| Anwendung: | Dopamine receptor agonist |
| CAS | 65273-66-7 |
| MW: | 318.2 D |
ab 73,00 €
Anti-DRD4
Artikelnummer: ARG55202.100
Protein function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating...
| Schlagworte: | Anti-DRD4, Anti-Dopamine D4 receptor, Anti-D(4) dopamine receptor, Anti-D(2C) dopamine receptor |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
608,00 €
IL-8 (guinea pig) Do-It-Yourself ELISA
Artikelnummer: DIY0933GP-004
The Guinea Pig IL-8 Do-It-Yourself ELISA contains capture antibody, standard, and detection antibody for development of a Guinea Pig IL-8 ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and...
| Schlagworte: | Drd4, Dopamine D4 receptor, D(4) dopamine receptor, D(2C) dopamine receptor |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | guinea pig |
ab 1.098,00 €
RBI 257 (maleate)
Artikelnummer: Cay17223-1
RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.Formal Name: N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate. CAS Number:...
| Schlagworte: | N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate |
| Anwendung: | D4 receptor antagonist |
| CAS | 911378-38-6 |
| MW: | 581.4 D |
ab 102,00 €
Anti-DRD4
Artikelnummer: E-AB-12360.120
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic...
| Schlagworte: | Anti-DRD4, Anti-Dopamine D4 receptor, Anti-D(4) dopamine receptor, Anti-D(2C) dopamine receptor, DRD4 Polyclonal Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
(R)-Pramipexole (hydrochloride)
Artikelnummer: Cay18234-50
Pramipexole (Cay-11981) is an agonist of dopamine receptors that has applications in Parkinson's disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of...
| Schlagworte: | (+)-Pramipexole, Dexpramipexole, KNS 760704, SND 919CL2X, 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine,... |
| Anwendung: | Dopamine receptor agonist control |
| CAS | 104632-27-1 |
| MW: | 284.2 D |
ab 97,00 €
Sonepiprazole
Artikelnummer: Cay11983-1
Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as alpha1- and alpha2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical...
| Schlagworte: | PNU 101387, U-101387, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-benzenesulfonamide |
| Anwendung: | Dopamine D4 DRD4 antagonist |
| CAS | 170858-33-0 |
| MW: | 401.5 D |
ab 67,00 €
Fluoroclebopride
Artikelnummer: Cay23447-5
Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1,...
| Schlagworte: | 4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-benzamide |
| Anwendung: | PET, dopamine receptor binding |
| CAS | 154540-49-5 |
| MW: | 391.9 D |
ab 56,00 €
ABT-724 (hydrochloride)
Artikelnummer: Cay29506-10
ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Galphaqo5. It is selective for dopamine D4 over D2 receptors at 10 µM. ABT-724 (0.03 µmol/kg) induces penile erections in 77% of male rats. It decreases...
| Schlagworte: | 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride |
| Anwendung: | Dopamine D4 receptor agonist |
| CAS | 587870-77-7 |
| MW: | 402.8 D |
ab 77,00 €