ABBV-744

ABBV-744 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2, Kis = 4.6, 4.9, 1.6, and 1 nM for BRD2, -3, -4, and -T, respectively). It is selective for BD2 over BD1 bromodomains in a time-resolved FRET (TR-FRET) assay (Kis = 1,162, 3,140, 521, and 917 nM for BRD2, -3, -4, and -T, respectively). ABBV-744 inhibits proliferation of SKM-1 leukemia cells (IC50 = 6.7 nM). It induces cell cycle arrest at the G1 phase in LNCaP prostate cancer cells. ABBV-744 (18.8 mg/kg) reduces tumor volume in a SKM-1 mouse xenograft model. It also reduces tumor growth in LNCaP and MDA PCa 2b mouse xenograft models when administered at doses of 1 and 4.7 mg/kg.Formal Name: N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide. CAS Number: 2138861-99-9. Molecular Formula: C28H30FN3O4. Formula Weight: 491.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC(C)(O)C1=CC=C(OC2=C(C)C=C(F)C=C2C)C(C3=CN(C)C(C4=C3C=C(C(NCC)=O)N4)=O)=C1. InChi Code: InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17(28(4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1-6H3,(H,30,33). InChi Key: OEDSFMUSNZDJFD-UHFFFAOYSA-N.