A2AR Agonist-1

A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1, Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively). It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington's disease when administered at a dose of 20 mg/kg. A2AR agonist-1 (0.11 mg/kg) also rescues motor performance and increases survival in a transgenic mouse model of Huntington's disease.Formal Name: N-[2-(1H-indol-3-yl)ethyl]-adenosine. CAS Number: 41552-95-8. Synonyms: JMF 1907. Molecular Formula: C20H22N6O4. Formula Weight: 410.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. lambdamax: 272, 364 nm. SMILES: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NCCC4=CNC5=C4C=CC=C5)N=CN=C32. InChi Code: InChI=1S/C20H22N6O4/c27-8-14-16(28)17(29)20(30-14)26-10-25-15-18(23-9-24-19(15)26)21-6-5-11-7-22-13-4-2-1-3-12(11)13/h1-4,7,9-10,14,16-17,20,22,27-29H,5-6,8H2,(H,21,23,24)/t14-,16-,17-,20-/m1/s1. InChi Key: QGCNEMXXKWZPHR-WVSUBDOOSA-N.