A2793

A2793 is an inhibitor of the two-pore domain potassium channel K2P18.1/TRESK (IC50 = 6.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor). It is selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM but does inhibit K2P3.1/TASK1.Formal Name: 2-[(5-chloro-8-quinolinyl)oxy]-acetic acid, ethyl ester. CAS Number: 88349-90-0. Molecular Formula: C13H12ClNO3. Formula Weight: 265.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: ClC(C1=C2N=CC=C1)=CC=C2OCC(OCC)=O. InChi Code: InChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3. InChi Key: JEMXUSHXYOXNFL-UHFFFAOYSA-N.