A-582941

An agonist of a7 nAChRs, induces inward currents in Xenopus oocytes expressing the rat or human receptor (EC50s = 2.45 and 4.26 µM, respectively), which can be reversed by methyllycaconitine, selectively binds to a7 nAChRs (Kis = 10.8 and 16.7 nM for the rat and human receptors, respectively) over a panel of >75 receptors and ion channels, including muscarinic receptors, at 10 µM but does bind to 5-HT3 (Ki = 154 nM), improves cognitive deficits in the 3xTg transgenic mouse model of Alzheimer's disease at 12 mg/kg, increases accuracy in the DMTS test in rhesus monkeys at 10 mg/kg. Formulation: A solid. InChI: InChI=1S/C17H20N4.2ClH/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13,,/h2-8,14-15H,9-12H2,1H3,2*1H. InChIKey: PGTCSMQEIJMZTJ-UHFFFAOYSA-N. SMILES: CN1CC2CN(C(N=N3)=CC=C3C4=CC=CC=C4)CC2C1.Cl.Cl