A-484954

A-484954 is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K, IC50 = 420 nM). It reduces eEF-2K autophosphorylation in PC3, HeLa, H460, H1299, and MDA-MB-231 cancer cells when used at a concentration of 75 µM.Formal Name: 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide. CAS Number: 142557-61-7. Molecular Formula: C13H15N5O3. Formula Weight: 289.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 229, 287, 333 nm. SMILES: O=C1N(CC)C(C(C=C(C(N)=O)C(N)=N2)=C2N1C3CC3)=O. InChi Code: InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19). InChi Key: HWODCHXORCTEGU-UHFFFAOYSA-N.