A-1899

A-1899 is an inhibitor of the two-pore domain potassium channel 3. (K2P3.1/TASK1, IC50 = 0. µM in Xenopus oocytes expressing the human channel). It is selective for K2P3.1/TASK1 over K2P5.1/TASK2, K2P9.1/TASK3, and K2P17.1/TASK4 (IC50s = 12, 0. and 8. µM, respectively) and a panel of 16 additional potassium channels at 0. µM. A-1899 (3 mg/kg) selectively increases the effective refractory period (ERP) in the left atrium over the right atrium and does not affect ventricular repolarization in anesthetized pigs. It stimulates breathing and induces respiratory alkalosis in spontaneously breathing anesthetized rats when administered at a dose of 25 mg/kg.. Solulibility: DMSO: Soluble: =10 mg/ml: .