8-Gingerol

8-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It contains the same aromatic region and polar link but has a longer hydrophobic tail than the more abundant 6-gingerol (Cay-11707). Like 6-gingerol, 8-gingerol activates the transient receptor potential vanilloid receptor 1 (TRPV1, EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pylori in vitro. 8-Gingerol also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates beta-agonist-induced relaxation of airway smooth muscle. Oral 8-gingerol is expected to be readily absorbed and rapidly metabolized by glucuronidation and sulfation, with minimal to modest effects on cytochrome P450 isoforms.Formal Name: 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone. CAS Number: 23513-08-8. Molecular Formula: C19H30O4. Formula Weight: 322.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 281 nm. SMILES: OC1=CC=C(CCC(C[C@@H](O)CCCCCCC)=O)C=C1OC. InChi Code: InChI=1S/C19H30O4/c1-3-4-5-6-7-8-16(20)14-17(21)11-9-15-10-12-18(22)19(13-15)23-2/h10,12-13,16,20,22H,3-9,11,14H2,1-2H3/t16-/m0/s1. InChi Key: BCIWKKMTBRYQJU-INIZCTEOSA-N. Origin: Plant/Zingiber officinale.