8-CPT-Cyclic AMP (sodium salt)

8-CPT-Cyclic AMP is a lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG (Ka = 0.05 and 0.11 µM, respectively). 8-CPT-cAMP inhibits cyclic GMP-specific phosphodiesterase (PDE VA), cyclic GMP-inhibited phosphodiesterase (PDE III), and cyclic AMP-specific phosphodiesterase (PDE IV) with IC50 values of 0.9, 24, and 25 µM, respectively. It has been used in studies to analyze the signal transduction pathways initiated by cyclic-AMP- and cyclic-GMP-dependent protein kinases.Formal Name: 8-[(4-chlorophenyl)thio]-cyclic 3',5'-(hydrogen phosphate)-adenosine, monosodium salt. CAS Number: 93882-12-3. Synonyms: 8-(p-Chlorophenylthio)-cAMP, 8-CPT-cAMP. Molecular Formula: C16H14ClN5O6PS . Na. Formula Weight: 493.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 25 mg/ml. lambdamax: 221, 282 nm. SMILES: O[C@H]1[C@H](N2C(SC3=CC=C(Cl)C=C3)=NC4=C2N=CN=C4N)O[C@H]5[C@H]1OP(OC5)([O-])=O.[Na+]. InChi Code: InChI=1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12,/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20),/q,+1/p-1/t9-,11-,12-,15-,/m1./s1. InChi Key: YIJFVHMIFGLKQL-DNBRLMRSSA-M.