5-Ph-IAA

5-Ph-IAA is a phenylic substituted indole and ligand used for bump and hole, a technique used to study single protein isoforms when familial homology would interfere with other isoform-selective approaches. It activates a bump-and-hole-modified protein, transport inhibitor response 1 (TIR1), which forms a PROTAC-associated complex that targets and degrades sister chromatid cohesion 1 (RAD21) and induces cell cycle arrest at the G2 or M phase in Arabidopsis when used at a concentration of 1 µM. Intraperitoneal administration of 5-Ph-IAA (1, 3, or 10 mg/kg per day) reduces tumor growth via the same process by targeting and degrading bromodomain-containing protein 4 (BRD4) in an HCT116 colorectal cancer xenograft mouse model.Formal Name: 5-phenyl-1H-indole-3-acetic acid. CAS Number: 168649-23-8. Molecular Formula: C16H13NO2. Formula Weight: 251.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.20 mg/ml. lambdamax: 253 nm. SMILES: O=C(CC1=CNC2=CC=C(C3=CC=CC=C3)C=C21)O. InChi Code: InChI=1S/C16H13NO2/c18-16(19)9-13-10-17-15-7-6-12(8-14(13)15)11-4-2-1-3-5-11/h1-8,10,17H,9H2,(H,18,19). InChi Key: ACCCWYHBDGKDKN-UHFFFAOYSA-N.