5-LOX inhibitor

Description: 5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor. Target: Lipoxygenase. Smiles: CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(O)cc2)c1=O. References: Pace JR,et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28,59(8):3635-49.