5-hydroxymethyl Tolterodine (formate)

5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine (Cay-15027) and fesoterodine (Cay-23777). It is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases. 5-hydroxymethyl Tolterodine inhibits M1-5 muscarinic receptors with Ki values of 2.3, 2, 2.5, 2.8, and 2.9 nM, respectively, for the human receptors expressed in CHO cells. It selectively inhibits acetylcholine-induced bladder contraction over electrically induced salivation in anesthetized cats (ID50s = 15 and 40 nmol/kg, respectively).Formal Name: formic acid, compd. with 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol. CAS Number: 380636-49-7. Synonyms: 5-HMT, Desfesoterodine, PNU 200577. Molecular Formula: C22H31NO2 . CH2O2. Formula Weight: 387.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(CO)C=C1.OC=O. InChi Code: InChI=1S/C22H31NO2.CH2O2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25,2-1-3/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3,1H,(H,2,3)/t20-,/m1./s1. InChi Key: YXSFRJSZLSBBRR-VEIFNGETSA-N.