5'-Deoxy-5'-methylthioadenosine

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 µM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.Formal Name: 5'-S-methyl-5'-thio-adenosine. CAS Number: 2457-80-9. Synonyms: 5'-S-Methylthioadenosine, MTA, NSC 335422, Vitamin L2. Molecular Formula: C11H15N5O3S. Formula Weight: 297.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 260 nm. SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3. InChi Code: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1. InChi Key: WUUGFSXJNOTRMR-IOSLPCCCSA-N.