5-BDBD

A P2X4 receptor antagonist (IC50 = 0.75 µM), selective for P2X4 over P2X1, P2X2a, P2X2b, and P2X7 but does inhibit P2X3 by 35.9% at 10 µM, decreases fEPSP slopes in rat hippocampal slices at 10 µM, inhibits nitroglycerin-induced mechanical hyperalgesia in a mouse model of chronic migraine at 28 mg/kg, decreases plasma creatinine and blood urea nitrogen levels, renal tubular necrosis and apoptosis, and renal neutrophil infiltration in a mouse model of ischemia-reperfusion-induced acute kidney injury, decreases infarct volume and improves neurological deficits in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg. Formulation: A solid. InChI: InChI=1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21). InChIKey: NKYMVQPXXTZHSF-UHFFFAOYSA-N. SMILES: BrC1=CC=CC(C2=NCC(NC3=C2OC4=CC=CC=C43)=O)=C1