4-IBP

4-IBP is a sigma-1 (sigma1) receptor ligand (Ki = 1.7 nM). It is selective for sigma1 over sigma2 receptors (Ki = 25.2 nM). It inhibits the growth and migration of PC3 prostate cancer and A549 non-small cell lung cancer (NSCLC) cells, as well as the migration of C32 melanoma and U373 MG glioblastoma cells, when used at a concentration of 10 µM. 4-IBP (2 mg/kg) increases survival in a U373 MG mouse xenograft model. It also increases firing of serotonergic neurons in the rat dorsal raphe nucleus when administered at a dose of 2 mg/kg.Formal Name: 4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]-benzamide. CAS Number: 155798-08-6. Synonyms: NSC 667672. Molecular Formula: C19H21IN2O. Formula Weight: 420.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 100µg/ml. lambdamax: 252 nm. SMILES: O=C(C1=CC=C(C=C1)I)NC2CCN(CC2)CC3=CC=CC=C3. InChi Code: InChI=1S/C19H21IN2O/c20-17-8-6-16(7-9-17)19(23)21-18-10-12-22(13-11-18)14-15-4-2-1-3-5-15/h1-9,18H,10-14H2,(H,21,23). InChi Key: HELCSESNNDZLFM-UHFFFAOYSA-N.