360A (iodide)

360A is an inhibitor of telomerase (IC50 = 0. µM). It decreases the viability of in T98G glioma fibroblasts, CB193 astrocytoma and U-118 MG glioma cells, and primary human astrocytes (IC50s = 4. 3. 8. and 17. µM, respectively). 360A (5 µM) induces sister chromatid fusions and telomere loss in HeLa cervical cancer cells. It induces cell cycle arrest at the S phase and increases gamma histone H2AX (gammaH2AX) foci, a marker of DNA damage, in GM03657 B cell lymphocytes.. Solulibility: DMSO: Slightly Soluble: 0.1-1 mg/ml: .