3-O-methyl Tolcapone

3-O-methyl Tolcapone is a stabilizer of transthyretin (TTR) and a metabolite of tolcapone (Cay-20768). Unlike tolcapone, 3-O-methyl tolcapone does not inhibit catechol-O-methyltransferase (COMT) and is not cytotoxic to SH-SY5Y or HepG2 cells (EC50s = 226.3 and 262.3 µM, respectively). 3-O-methyl Tolcapone (1 and 10 µM) stabilizes TTR in isolated human plasma and binds to TTR in a cell-free assay (Kd = 33 nM).. SMILES: O=C(C1=CC(OC)=C(C([N+]([O-])=O)=C1)O)C2=CC=C(C)C=C2. InChi Code: InChI=1S/C15H13NO5/c1-9-3-5-10(6-4-9)14(17)11-7-12(16(19)20)15(18)13(8-11)21-2/h3-8,18H,1-2H3. InChi Key: VCNSNEJUGBEWTA-UHFFFAOYSA-N