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3-O-methyl Tolcapone
3-O-methyl Tolcapone

Artikelnummer: Cay45833-10

3-O-methyl Tolcapone is a stabilizer of transthyretin (TTR) and a metabolite of tolcapone (Cay-20768). Unlike tolcapone, 3-O-methyl tolcapone does not inhibit catechol-O-methyltransferase (COMT) and is not cytotoxic to SH-SY5Y or HepG2 cells (EC50s = 226.3 and 262.3 µM, respectively). 3-O-methyl Tolcapone (1 and 10...
Schlagworte: 3-OMT, Ro 40-7591, (4-hydroxy-3-methoxy-5-nitrophenyl)(4-methylphenyl)-methanone
Anwendung: TTR stabilizer, tolcapone metabolite
CAS 134612-80-9
MW: 287.27 D
ab 40,00 €
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3-O-Methyltolcapone
3-O-Methyltolcapone

Artikelnummer: TGM-T10119-100mg

Description: 3-O-Methyltolcapone (Ro 40-7591), a metabolite of Tolcapone, is a potent COMT inhibitor that crosses the blood-brain barrier and can be used for the treatment of Parkinson's disease. Target: Transferase. Smiles: COc1cc(cc(c1O)[N+]([O-])=O)C(=O)c1ccc(C)cc1. References: Jorga K, et al. Metabolism and...
Schlagworte: Ro 40-7591
CAS 134612-80-9
MW: 287.27 D
2.371,00 €
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