3-Methylglutaric acid

Description: Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, another inborn error of metabolism. Target: Endogenous Metabolite. Smiles: C(C(CC(O)=O)C)C(O)=O. References: Sreekumar A , Poisson L M , Rajendiran T M , et al. Corrigendum: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression[J]. Nature, 2009, 457(7231):910-914.