3-Deazaadenosine

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 µM). It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-kappaB signaling. 3-DZA also has antiviral and antibacterial activities.Formal Name: 1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine. CAS Number: 6736-58-9. Synonyms: c3Ado, deaza-Ado, 3-DZA. Molecular Formula: C11H14N4O4. Formula Weight: 266.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 267 nm. SMILES: NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=CC=N1. InChi Code: InChI=1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1. InChi Key: DBZQFUNLCALWDY-PNHWDRBUSA-N.