24(S)-hydroxy Cholesterol

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver. 24(S)-hydroxy cholesterol potently activates LXRalpha and LXRbeta nuclear receptors (EC50 = 4 and 3 µM, respectively), causing upregulation of cholesterol-lowering genes. In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer's disease and other neuropathological conditions.Formal Name: cholest-5-ene-3beta,24S-diol. CAS Number: 474-73-7. Synonyms: Cerebrosterol. Molecular Formula: C27H46O2. Formula Weight: 402.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 100 µg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2): 500 µg/ml. SMILES: O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@]4([C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](O)C(C)C)C)C)([H])[C@](C)2CC1. InChi Code: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1. InChi Key: IOWMKBFJCNLRTC-XWXSNNQWSA-N.