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T0901317
T0901317

Artikelnummer: Cay71810-10

The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
Schlagworte: N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Anwendung: LXRalpha agonist, LXRbeta agonist
CAS 293754-55-9
MW: 481.3 D
ab 54,00 €
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LXRb Reporter Assay System (dog)
LXRb Reporter Assay System (dog)

Artikelnummer: IB-D00301

Schlagworte: Nuclear receptor subfamily 1 group H member 2
Anwendung: Functional activity screening
Spezies-Reaktivität: dog
1.448,00 €
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25(R)-27-hydroxy Cholesterol
25(R)-27-hydroxy Cholesterol

Artikelnummer: Cay14790-1

The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Schlagworte: (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol
Anwendung: LXR alpha / beta activator
CAS 20380-11-4
MW: 402.7 D
ab 77,00 €
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Dendrogenin A
Dendrogenin A

Artikelnummer: Cay37975-1

Dendrogenin A (DDA) is a selective liver X receptor (LXR) modulator (SLiM), an inhibitor of cholesterol epoxide hydrolase (ChEH, Ki = 120 nM), and an active metabolite of cholesterol. It is formed from 5,6alpha-epoxy cholesterol via conjugation with histamine by DDA synthase. DDA is found in non-cancerous human...
Schlagworte: DDA, (3beta,5alpha,6beta)-6-[[2-(1H-imidazol-5-yl)ethyl]amino]-cholestane-3,5-diol
Anwendung: Selective liver X receptor (LXR) modulator (SLiM), ChEH inhibitor
CAS 1191043-85-2
MW: 513.8 D
ab 42,00 €
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24(S)-hydroxy Cholesterol
24(S)-hydroxy Cholesterol

Artikelnummer: Cay10009931-1

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...
Schlagworte: Cerebrosterol, cholest-5-ene-3beta,24S-diol
Anwendung: LXR alpha / beta agonist
CAS 474-73-7
MW: 402.7 D
ab 92,00 €
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24alpha-methyl Cholesterol
24alpha-methyl Cholesterol

Artikelnummer: Cay17344-1

24-methyl Cholesterol is a phytosterol found in vegetables, fruits, nuts, and seeds that competitively inhibits the absorption of intestinal cholesterol and decreases the transcription of genes important for cholesterol metabolism. The cholesterol lowering effects of phytosterols, such as 24-methyl cholesterol, have...
Schlagworte: Campesterol, NSC 224330, (3beta,24R)-ergost-5-en-3-ol
Anwendung: Phytosterol, LXR agonist
CAS 23929-42-2
MW: 400.7 D
ab 98,00 €
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GW 3965 (hydrochloride)
GW 3965 (hydrochloride)

Artikelnummer: Cay10054-10

The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
Schlagworte: 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride
Anwendung: LXR alpha / beta agonist
CAS 405911-17-3
MW: 618.5 D
ab 53,00 €
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24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol

Artikelnummer: Cay10131-1

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone...
Schlagworte: 24(S)-24,25-EC, (3beta,24S)-24,25-epoxy-cholest-5-en-3-ol
Anwendung: Oxysterol, LXR activator
CAS 77058-74-3
MW: 400.6 D
271,00 €
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LXRbeta (human) Reporter Assay Kit
LXRbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB00302

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRbeta. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
3.802,00 €
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BMS 779788
BMS 779788

Artikelnummer: Cay27339-1

BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...
Schlagworte: 2-[1-(2-chlorophenyl)-1-methylethyl]-alpha,alpha-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol
Anwendung: LXR alpha & beta partial agonist
CAS 918348-67-1
MW: 509.1 D
ab 77,00 €
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SR9238
SR9238

Artikelnummer: Cay18771-10

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...
Schlagworte: 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic...
Anwendung: LXRA / LXRB inverse agonist
CAS 1416153-62-2
MW: 595.7 D
ab 44,00 €
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25(S)-27-hydroxy Cholesterol
25(S)-27-hydroxy Cholesterol

Artikelnummer: Cay14791-5

The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Schlagworte: (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol
Anwendung: LXR alpha / beta activator
CAS 56845-83-1
MW: 402.7 D
ab 77,00 €
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