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Zu "K08535" wurden 50 Artikel gefunden!
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Artikelnummer: Cay71810-10
The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
Schlagworte: | N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
Anwendung: | LXRalpha agonist, LXRbeta agonist |
CAS | 293754-55-9 |
MW: | 481.3 D |
ab 54,00 €
Artikelnummer: IB-D00301
Schlagworte: | Nuclear receptor subfamily 1 group H member 2 |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | dog |
1.448,00 €
Artikelnummer: Cay14790-1
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Schlagworte: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
Anwendung: | LXR alpha / beta activator |
CAS | 20380-11-4 |
MW: | 402.7 D |
ab 77,00 €
Artikelnummer: Cay37975-1
Dendrogenin A (DDA) is a selective liver X receptor (LXR) modulator (SLiM), an inhibitor of cholesterol epoxide hydrolase (ChEH, Ki = 120 nM), and an active metabolite of cholesterol. It is formed from 5,6alpha-epoxy cholesterol via conjugation with histamine by DDA synthase. DDA is found in non-cancerous human...
Schlagworte: | DDA, (3beta,5alpha,6beta)-6-[[2-(1H-imidazol-5-yl)ethyl]amino]-cholestane-3,5-diol |
Anwendung: | Selective liver X receptor (LXR) modulator (SLiM), ChEH inhibitor |
CAS | 1191043-85-2 |
MW: | 513.8 D |
ab 42,00 €
Artikelnummer: Cay10009931-1
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...
Schlagworte: | Cerebrosterol, cholest-5-ene-3beta,24S-diol |
Anwendung: | LXR alpha / beta agonist |
CAS | 474-73-7 |
MW: | 402.7 D |
ab 92,00 €
Artikelnummer: Cay17344-1
24-methyl Cholesterol is a phytosterol found in vegetables, fruits, nuts, and seeds that competitively inhibits the absorption of intestinal cholesterol and decreases the transcription of genes important for cholesterol metabolism. The cholesterol lowering effects of phytosterols, such as 24-methyl cholesterol, have...
Schlagworte: | Campesterol, NSC 224330, (3beta,24R)-ergost-5-en-3-ol |
Anwendung: | Phytosterol, LXR agonist |
CAS | 23929-42-2 |
MW: | 400.7 D |
ab 98,00 €
Artikelnummer: Cay10054-10
The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
Schlagworte: | 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride |
Anwendung: | LXR alpha / beta agonist |
CAS | 405911-17-3 |
MW: | 618.5 D |
ab 53,00 €
Artikelnummer: Cay10131-1
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone...
Schlagworte: | 24(S)-24,25-EC, (3beta,24S)-24,25-epoxy-cholest-5-en-3-ol |
Anwendung: | Oxysterol, LXR activator |
CAS | 77058-74-3 |
MW: | 400.6 D |
271,00 €
Artikelnummer: IB-IB00302
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRbeta. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: | LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear... |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | human |
3.802,00 €
Artikelnummer: Cay27339-1
BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...
Schlagworte: | 2-[1-(2-chlorophenyl)-1-methylethyl]-alpha,alpha-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol |
Anwendung: | LXR alpha & beta partial agonist |
CAS | 918348-67-1 |
MW: | 509.1 D |
ab 77,00 €
Artikelnummer: Cay18771-10
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...
Schlagworte: | 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic... |
Anwendung: | LXRA / LXRB inverse agonist |
CAS | 1416153-62-2 |
MW: | 595.7 D |
ab 44,00 €
Artikelnummer: Cay14791-5
The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Schlagworte: | (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol |
Anwendung: | LXR alpha / beta activator |
CAS | 56845-83-1 |
MW: | 402.7 D |
ab 77,00 €