Zu "K08535" wurden 64 Artikel gefunden!
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T0901317
Artikelnummer: Cay71810-10
The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
| Schlagworte: | N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
| Anwendung: | LXRalpha agonist, LXRbeta agonist |
| CAS | 293754-55-9 |
| MW: | 481.3 D |
ab 68,00 €
25(R)-27-hydroxy Cholesterol
Artikelnummer: Cay14790-1
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 20380-11-4 |
| MW: | 402.7 D |
ab 85,00 €
24(S)-hydroxy Cholesterol
Artikelnummer: Cay10009931-1
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...
| Schlagworte: | Cerebrosterol, cholest-5-ene-3beta,24S-diol |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 474-73-7 |
| MW: | 402.7 D |
ab 102,00 €
RGX-104
Artikelnummer: Cay42120-10
An LXRa and LXRß agonist, induces recruitment of an SRC-1 fragment in cell-free FRET-based assays (EC50s = 74 and 25 nM for LXRa and LXRß, respectively), induces cholesterol efflux in RAW 264.7 macrophages (EC50 = 17 nM), increases plasma levels of VLDL, LDL, and triglycerides in hamsters at 10 mg/kg twice per day...
| Schlagworte: | Abequolixron, SB-742881,... |
| Anwendung: | LXRa / LXRbeta agonist |
| CAS | 610318-54-2 |
| MW: | 596.08 D |
ab 147,00 €
24(S),25-epoxy Cholesterol
Artikelnummer: Cay10131-1
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone...
| Schlagworte: | 24(S)-24,25-EC, (3beta,24S)-24,25-epoxy-cholest-5-en-3-ol |
| Anwendung: | Oxysterol, LXR activator |
| CAS | 77058-74-3 |
| MW: | 400.6 D |
301,00 €
GW 3965 (hydrochloride)
Artikelnummer: Cay10054-10
The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
| Schlagworte: | 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 405911-17-3 |
| MW: | 618.5 D |
ab 38,00 €
LXRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00302
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | LXRB, NR1H2, Nuclear receptor NER, Liver X receptor beta, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
GSK2033
Artikelnummer: Cay25443-5
GSK2033 is an antagonist of liver X receptor alpha (LXRalpha) and LXRbeta (IC50s = 0.1 and 0.398 µM, respectively) that has no agonist activity in an LXR transactivation assay. It inhibits LXR agonist-induced and basal expression of the LXR target genes ATP-binding cassette transporter 1 (ABCA1) and sterol...
| Schlagworte: | 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfo... |
| Anwendung: | LXRalpha / LXRbeta antagonist |
| CAS | 1221277-90-2 |
| MW: | 591.7 D |
ab 49,00 €
BMS 779788
Artikelnummer: Cay27339-1
BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...
| Schlagworte: | 2-[1-(2-chlorophenyl)-1-methylethyl]-alpha,alpha-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol |
| Anwendung: | LXR alpha & beta partial agonist |
| CAS | 918348-67-1 |
| MW: | 509.1 D |
ab 85,00 €
SR9238
Artikelnummer: Cay18771-10
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...
| Schlagworte: | 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic... |
| Anwendung: | LXRA / LXRB inverse agonist |
| CAS | 1416153-62-2 |
| MW: | 595.7 D |
ab 50,00 €
25(S)-27-hydroxy Cholesterol
Artikelnummer: Cay14791-5
The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 56845-83-1 |
| MW: | 402.7 D |
ab 85,00 €
SR9243
Artikelnummer: Cay18420-1
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer...
| Schlagworte: | N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-benzenesulfonamide |
| Anwendung: | Cell-permeable LXR inverse agonist |
| CAS | 1613028-81-1 |
| MW: | 626.6 D |
ab 49,00 €