2-Iminobiotin hydrobromide

Description: 2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS, Ki of 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively). Target: NOS, NO Synthase. Smiles: [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br. References: Sup S J , Green B G , Grant S K . 2-Iminobiotin Is an Inhibitor of Nitric Oxide Synthases[J]. Biochemical & Biophysical Research Communications, 1994, 204(2):0-968.