2-cyano-Pyrimidine

Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis. 2-cyano-Pyrimidine has an IC50 value of 170 nM for inhibition of cathepsin K.Formal Name: 2-pyrimidinecarbonitrile. CAS Number: 14080-23-0. Molecular Formula: C5H3N3. Formula Weight: 105.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 213, 254 nm. SMILES: NCc1ncccn1. InChi Code: InChI=1S/C5H3N3/c6-4-5-7-2-1-3-8-5/h1-3H. InChi Key: IIHQNAXFIODVDU-UHFFFAOYSA-N.