2'-C-Methylcytidine

2'-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 µM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 µM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV, EC50 = 2.2 µM) and human coronavirus (HCoV, EC50 = 90 µM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV, EC50 = 6.4 µM) and swine vesicular disease virus (SVDV, EC50 = 45.2 µM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.Formal Name: 2'-C-methyl-cytidine. CAS Number: 20724-73-6. Synonyms: 2CMC. Molecular Formula: C10H15N3O5. Formula Weight: 257.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 275 nm. SMILES: O=C(N=C(N)C=C1)N1[C@H]2[C@](C)(O)[C@H](O)[C@@H](CO)O2. InChi Code: InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1. InChi Key: PPUDLEUZKVJXSZ-VPCXQMTMSA-N.