2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.Formal Name: 2,4-diamino-6(1H)-pyrimidinone. CAS Number: 56-06-4. Synonyms: DAHP. Molecular Formula: C4H6N4O. Formula Weight: 126.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >14.4 mg/ml, DMSO: >14.6 mg/ml, Ethanol: <50 µg/ml, PBS pH 7.2: >3.3 mg/ml. SMILES: Nc1cc(O)nc(N)n1. InChi Code: InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9). InChi Key: SWELIMKTDYHAOY-UHFFFAOYSA-N.