2',3',5'-triacetyl-5-Azacytidine

2',3',5'-triacetyl-5-Azacytidine is a prodrug form of the DNA methyltransferase inhibitor 5-azacytidine (Cay-11164). It decreases promoter methylation of P15 in L1210 mouse leukemia cells when used at concentrations of 1 and 100 µM. 2',3',5'-triacetyl-5-Azacytidine (10 µM) reduces HIV-1 infection in, and increases the viability of, unstimulated primary human CD4+ T cells. It decreases gut and spleen global DNA methylation levels in mice when administered at a dose of 38 mg/kg per day for 5 consecutive days.Formal Name: 4-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one. CAS Number: 10302-78-0. Molecular Formula: C14H18N4O8. Formula Weight: 370.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C1N([C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]2OC(C)=O)C=NC(N)=N1. InChi Code: InChI=1S/C14H18N4O8/c1-6(19)23-4-9-10(24-7(2)20)11(25-8(3)21)12(26-9)18-5-16-13(15)17-14(18)22/h5,9-12H,4H2,1-3H3,(H2,15,17,22)/t9-,10-,11-,12-/m1/s1. InChi Key: OTQJVHISAFFLMA-DDHJBXDOSA-N.