[10]-Gingerol

Light-yellow powder. Soluble in DMSO (25mg/ml), DMF (30mg/ml), ethanol (15mg/ml) or methanol (5mg/ml). Chemical. CAS: 23513-15-7. Formula: C21H34O4. MW: 350.49. Isolated from plant source. 10-Gingerol is originally found in species of Zingiber. It exhibits antiemetic, anticancer, antioxidative, anti-inflammatory and antibiotic activities. 10-Gingerol increases radical scavenging of superoxide and hydroxyl radicals, inhibits oxidative burst activity and decreases expression of NO and PGE2 in vitro. It exhibits antioxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation. 10-Gingerol also inhibits 5-HT3 receptors. Additionally, 10-gingerol inhibits proliferation in different cancer cells. Shwon to suppresses IL-2-induced proliferation of T lymphocytes. This compound also displays antibacterial efficacy against gram negative bacteria such as Porphyromonas and Prevotella, antifungal and antiparasitic activity.