Tiamulin (fumarate)

Tiamulin is a pleuromutilin antibiotic. It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA). Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.Formal Name: 2-[[2-(diethylamino)ethyl]thio]-acetic acid, (3aS,4R,5S,6S,8R,9S,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, 2E-butenedioate. CAS Number: 55297-96-6. Synonyms: 81723 Hfu, SQ 22,947. Molecular Formula: C28H47NO4S . C4H4O4. Formula Weight: 609.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 208 nm. SMILES: O=C1CC[C@@]2(CC[C@H]3C)[C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CSCCN(CC)CC)=O)[C@@]3(C)[C@@]21[H].OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28,5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3,1-2H,(H,5,6)(H,7,8)/b,2-1+/t19-,20+,22-,24+,25+,26-,27+,28+,/m1./s1. InChi Key: YXQXDXAHCSEVSD-GCYNEOGWSA-N.