Sulfapyridine

Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. It is also a metabolite of sulfasalazine (Cay-15025) formed through bacterial conversion in the colon. It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 µg/ml, respectively), as well as S. aureus (MBC = 0.8 µM). It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS, IC50 = 0.18 µM). Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay. It inhibits histamine release induced by compound 48/80 (Cay-22173) from isolated rat peritoneal mast cells in a dose-dependent manner. Sulfapyridine (1 µg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.Formal Name: 4-amino-N-2-pyridinyl-benzenesulfonamide. CAS Number: 144-83-2. Synonyms: NSC 41791, NSC 4753, Sulphapyridine. Molecular Formula: C11H11N3O2S. Formula Weight: 249.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 270 nm. SMILES: NC1=CC=C(S(NC2=CC=CC=N2)(=O)=O)C=C1. InChi Code: InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14). InChi Key: GECHUMIMRBOMGK-UHFFFAOYSA-N.