Splitomicin

Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone deacetylase activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 µM) than in vitro (IC50 = 60 µM). It less effectively inhibits yeast Hst1, a paralog of Sir2p. Splitomicin has diverse effects on mammalian cells.Formal Name: 1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one. CAS Number: 5690-03-9. Synonyms: 1-Naphthalenepropanoic Acid. Molecular Formula: C13H10O2. Formula Weight: 198.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C1CCc2c(ccc3ccccc23)O1. InChi Code: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2. InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N.