Kazusamycin A

Kazusamycin A is an antibiotic from Streptomyces and a hydroxy analog of Leptomycin B (Cay-10004976) that demonstrates cytotoxic activity against various human and mouse tumor lines. Additionally, at nanomolar concentrations, it inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome.Formal Name: (2E,5S,6R,7S,9S,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid. CAS Number: 92090-94-3. Synonyms: CL 1,957B, Hydroxyelactocin, Hydroxyleptomycin B, PD 114721. Molecular Formula: C33H48O7. Formula Weight: 556.7. Purity: >95%. Formulation: (Request formulation change), A film. SMILES: O=C1O[C@@H](/C=C/C(CC)=C\[C@H](C)C/C=C/C(C)=C/[C@@H](CO)C([C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C/C(O)=O)=O)[C@@H](C)C=C1. InChi Code: InChI=1S/C33H48O7/c1-8-27(13-14-29-24(5)12-15-31(37)40-29)17-21(2)10-9-11-22(3)18-28(20-34)33(39)26(7)32(38)25(6)16-23(4)19-30(35)36/h9,11-15,17-19,21,24-26,28-29,32,34,38H,8,10,16,20H2,1-7H3,(H,35,36)/b11-9+,14-13+,22-18+,23-19+,27-17-/t21-,24+,25+,. InChi Key: KZMHNEBMQDBQND-LBNZKSCFSA-N.