Hinokitiol

Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties. It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis. In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO, IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.Formal Name: 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one. CAS Number: 499-44-5. Synonyms: NSC 18804, beta-Thujaplicin, 4-isopropyl Tropolone. Molecular Formula: C10H12O2. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238, 320 nm. SMILES: O=C1C(O)=CC(C(C)C)=CC=C1. InChi Code: InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12). InChi Key: FUWUEFKEXZQKKA-UHFFFAOYSA-N.