Dapsone

Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound. In vivo, dapsone (34 µg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis. It reduces lipid peroxidation, myeloperoxidase activity, and cellular apoptosis in the striatum of rats following ischemia and reperfusion injury. Dapsone reduces growth of M. leprae in the footpad of mice (MIC = 0.01-0.03 µg/ml in sera) and induces clearance of P. knowlesi infections in macaques. It also reduces the number of P. gallinaceum sporozoites in a mosquito population allowed to feed on dapsone-treated chicks. Formulations containing dapsone have been used in the treatment of malaria, acne, dermatitis, and leprosy.Formal Name: 4,4'-sulfonylbis-benzenamine. CAS Number: 80-08-0. Synonyms: 4,4'-Diaminodiphenyl sulfone, NSC 6091. Molecular Formula: C12H12N2O2S. Formula Weight: 248.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. lambdamax: 261, 296 nm. SMILES: NC1=CC=C(S(C2=CC=C(N)C=C2)(=O)=O)C=C1. InChi Code: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2. InChi Key: MQJKPEGWNLWLTK-UHFFFAOYSA-N.