Chetomin

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1alpha and HIF-2alpha to p300 at low nanomolar concentrations. Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice. It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.Formal Name: 2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione. CAS Number: 1403-36-7. Synonyms: NSC 289491. Molecular Formula: C31H30N6O6S4. Formula Weight: 710.9. Purity: >95%. Formulation: (Request formulation change), An crystalline solid. Solubility: DMSO: 5 mg/ml. SMILES: O=C(C1(CC2=CN([C@@]34C5=CC=CC=C5N[C@]3([H])N(C([C@@]6(CO)N(C)C7=O)=O)[C@]7(SS6)C4)C8=C2C=CC=C8)N9C)N(C)[C@@](CO)(SS1)C9=O. InChi Code: InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28?,29+,30+,31+/m1/s. InChi Key: ZRZWBWPDBOVIGQ-ZVZGDCBQSA-N. Origin: Fungus/Chaetomium sp..