Ampicillin (sodium salt)

Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of S. pseudintermedius, S. aureus, E. coli, Pasteurella, and S. canis (MIC50s = 0.25, 0.5, 2, 0.12, and 0.25 µg/ml, respectively). In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (P. cynocephalus) model of pneumococcal pneumonia. Formulations containing ampicillin have been used to treat a variety of bacterial infections. Formal Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt. CAS Number: 69-52-3. Molecular Formula: C16H18N3O4S . Na. Formula Weight: 371.4. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O)[C@H](N)C3=CC=CC=C3.[Na+]. InChi Code: InChI=1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8,/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23),/q,+1/p-1/t9-,10-,11+,14-,/m1./s1. InChi Key: KLOHDWPABZXLGI-YWUHCJSESA-M.