TL1A CHO Cell Line

TL1A CHO Cell Line is a clonal CHO cell line expressing full-length human TL1A (TNF-like ligand 1A) (NM_005118.4). The expressed TL1A may be released as a soluble form by proteolytic cleavage. This cell line has been validated by flow cytometry, and in a co-culture assay with TL1A-Responsive Luciferase Reporter Jurkat Cell line (#78811) in the presence of a TL1A neutralizing antibody. TL1A, also known as TNFSF15 (tumor necrosis factor superfamily member 15) or VEGI (Vascular endothelial growth inhibitor), is a member of the tumor necrosis factor family. It is expressed in different immune cells, such as monocytes, macrophages, dendritic cells, T cells, and non-immune cells. TL1A competitively binds to DR3 (death receptor 3), having a higher affinity for DcR3 (decoy receptor 3), pand regulates proliferation, activation, apoptosis, and chemokine production in effector cells. The role of DR3 in T cell activation, and consequently in cytokine secretion and cell proliferation, makes it an attractive target in cancer therapy. Inhibition of DR3-TL1A interaction has substantial therapeutic potential in the treatment of solid tumors.