Resistin (human) ELISA Kit

Resistin (FIZZ3, ADSF, Adipose tissue-specific secretory factor) is a 12.5kDa cysteine-rich adipocytokine. In rodents, increased resistin-levels impair insulin action, while genetic ablation or down-regulation of the resistin gene improves insulin sensitivity. In humans most reports identified inflammatory cells and bone marrow-derived cells as the main source of resistin, indicating a role in inflammatory responses. Plasma resistin levels were shown to be associated with C-reactive protein (CRP), inflammatory bowel disease, Crohn's disease, atherosclerosis and acute pancreatitis. Atherosclerosis and obesity are increasingly viewed as chronic inflammatory conditions. Circulating resistin levels were reported to be increased in obesity and diabetes.