Mouse TrkB ELISA Kit

Mouse TrkB ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0510 1 kit - -

1 - 9 Werktage

728,00 €
 
Natural and recombinant mouse TrkB. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Mouse TrkB ELISA Kit"
Natural and recombinant mouse TrkB. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. [The UniProt Consortium]
Schlagworte: Trkb, Ntrk2, Trk-B, EC=2.7.10.1, GP145-TrkB/GP95-TrkB, TrkB tyrosine kinase, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0510

Eigenschaften

Anwendung: ELISA
Wirt: Mouse
Reaktivität: Mouse
Immunogen: Expression system for standard: NSO, Immunogen sequence: C32-H429
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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