Mouse Bone morphogenetic protein 2, BMP-2 ELISA Kit

Sample Types: serum, plasma, cell culture supernates, tissue homogenates Detection Range: 1.56 pg/mL-100 pg/mL Sensitivity: 0.39 pg/mL Assay Principle: quantitative Measurement: SandwichAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. [The UniProt Consortium]