Cdc42 Activation Assay Kit

Configuration-specific monoclonal antibody that recognizes Cdc42-GTP, but not Cdc42-GDP. The only available Cdc42 activation assay kit directly measures the level of Cdc42-GTP. Providing reliable results with consistent reproducibility than other Cdc42 activation assay kits based on certain downstream signaling pathways. Providing shorter experimental time. Could be used to monitor the activation of Cdc42 in cells and in tissues by immunohistochemistry Protein function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. [The UniProt Consortium]