Anti-Human TOP2B Antibody Pair

Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which alleviates torsional stress generated during these processes. TOP2B is characterized by its ability to bind ATP and catalyze the cleavage and religation of DNA strands, thus maintaining genomic integrity. Unlike its paralog TOP2A, TOP2B is expressed in both dividing and non-dividing cells and is essential for various cellular functions, including neuronal activity and gene regulation. Dysregulation of TOP2B has been implicated in several diseases, particularly cancer, where its activity can contribute to chromosomal translocations and mutations. Additionally, alterations in TOP2B expression have been linked to neurodevelopmental disorders and other conditions. Protein Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation [The Uniprot Consortium]