Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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CAR3 (human) Reporter Assay Kit
Artikelnummer: IB-IB00902
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human constitutive androstane receptor, isoform 3 (NR1I3), a ligand-dependent transcription factor commonly referred to as CAR3. These reporter cells utilize a modified...
| Schlagworte: | CAR, NR1I3, Constitutive active response, Orphan nuclear receptor MB67, Constitutive androstane receptor, Constitutive... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
TRalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB01002
This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRalpha. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | THRA, EAR7, EAR-7, c-erbA-1, c-erbA-alpha, V-erbA-related protein 7, Thyroid hormone receptor alpha, Nuclear receptor... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
TRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB01102
This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor beta (NR1A2), a ligand-dependent transcription factor commonly referred to as TRbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | THRB, ERBA2, c-erbA-2, c-erbA-beta, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
TR (human) Reporter Assays Panel
Artikelnummer: IB-IB01201-48P
INDIGO's panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A3) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRalpha and TRbeta. INDIGO's TR reporter cells include the luciferase reporter gene functionally...
| Schlagworte: | thyroid hormone receptor alpha (NR1A1), thyroid hormone receptor beta (NR1A2), Tralpha, TRbeta |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
2.176,00 €
RARgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB02002
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor gamma (NR1B3), a ligand-dependent transcription factor commonly referred to as RARG or RARgamma. INDIGO's reporter cells include the luciferase...
| Schlagworte: | RARG, NR1B3, RAR-gamma, Retinoic acid receptor gamma, Nuclear receptor subfamily 1 group B member 3 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
RARbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB02102
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
| Schlagworte: | HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
RARalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB02202
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...
| Schlagworte: | RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
RAR (human) Reporter Assays Panel
Artikelnummer: IB-IB02301-32P
INDIGO's panel of RAR reporter assays utilizes non-human mammalian cells engineered to individually express human retinoic acid receptors, RARalpha (NR1B1), RARbeta (NR1B2), or RARgamma (NR1B3). INDIGO's RAR reporter cells include the luciferase reporter gene functionally linked to a responsive promoter. Thus,...
| Schlagworte: | RARalpha, NR1B1, RARbeta, NR1B2, RARgamma, NR1B3, retinoic acid receptor alpha, retinoic acid receptor beta, retinoic acid... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
2.176,00 €
RORgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB04002
This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
| Schlagworte: | RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
ERRalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB08002
This nuclear receptor assay system utilizes proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of the human estrogen-related receptor alpha (NR3B1). The N-terminal DNA binding domains (DBD) of the native ERRalpha has been substituted with that of the yeast GAL4-DBD. The...
| Schlagworte: | ERR1, ESRRA, ERR-alpha, Estrogen receptor-like 1, Steroid hormone receptor ERR1, Estrogen-related receptor alpha, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
ERRgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB08022
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor gamma (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRgamma has been substituted with that of the yeast GAL4-DBD....
| Schlagworte: | Estrogen-Related Receptor gamma (human) Reporter Assay Kit, NR3B3, ERR3, ESRRG, ERR gamma-2, Estrogen-related receptor... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
NF-kappaB (Human) Reporter Assay System
Artikelnummer: IB-IB09002
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €