Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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NEU
AMY1R Reporter Assay System (human)
Artikelnummer: IB-IB48101
Protein Function: Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). Required for the transport of...
| Schlagworte: | RAMP1, Receptor activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
NEU
B1R Inhibition Reporter Assay System (human)
Artikelnummer: IB-IB50001
Protein Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation [The Uniprot Consortium]
| Schlagworte: | BDKRB1, B1 bradykinin receptor |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
NEU
B2R Inhibition Reporter Assay System (human)
Artikelnummer: IB-IB51001
Protein Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system [The Uniprot Consortium]
| Schlagworte: | BDKRB2, B2 bradykinin receptor |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
NEU
GPR39 Inhibition Reporter Assay System (human)
Artikelnummer: IB-IB52001
Protein Function: Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304)....
| Schlagworte: | GPR39, G-protein coupled receptor 39 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
1.705,00 €
NEU
Live Cell Assay
Artikelnummer: IB-LCA-01
| Anwendung: | Quantify relative changes in live mammalian cell number following treatment with test compounds |
323,00 €
NEU
Live Cell Assay
Artikelnummer: IB-LCA-05
| Anwendung: | Quantify relative changes in live mammalian cell number following treatment with test compounds |
1.264,00 €
NEU
Live Cell Assay
Artikelnummer: IB-LCA-10
| Anwendung: | Quantify relative changes in live mammalian cell number following treatment with test compounds |
1.588,00 €
NF-kappaB (Human) Reporter Assay System
Artikelnummer: IB-IB09001
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
MR (human) Reporter Assay Kit
Artikelnummer: IB-IB00502
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO's reporter cells include the luciferase...
| Schlagworte: | MR, MCR, NR3C2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
PPARgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB00101
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARgamma. INDIGO's reporter cells include...
| Schlagworte: | NR1C3, PPARG, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
PXR (human) Reporter Assay Kit
Artikelnummer: IB-IB07001
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Schlagworte: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Nrf2 (Human) Reporter Assay System
Artikelnummer: IB-IB10001-32
Protein function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating...
| Schlagworte: | NRF2, HEBP1, NFE2L2, NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €