Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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Fibroblast Growth Factor Receptors 1 & 2 for Paracrine...
Artikelnummer: IB-IB21001-32
The family of Fibroblast Growth Factors (FGFs) comprise approximately 23 members that are related by core sequence and structure conservation, with the majority of FGFs being secreted signaling proteins. Secreted FGFs are predominantly autocrine and paracrine factors, with only three members evolved to function as...
| Schlagworte: | CD331, FLT-2, FGFR1, BFGFR, N-sam, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
ab 1.588,00 €
GR (Mouse) Reporter Assay System
Artikelnummer: IB-M00201
Protein function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and...
| Schlagworte: | GR, Grl, Nr3c1, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | mouse |
ab 1.588,00 €
P-Glycoprotein / MDR1 (human) Drug Interaction Assay
Artikelnummer: IB-HPGP-48
The materials provided in the assay kit for MDR1 / Human P-Glycoprotein Drug Interaction are formatted to allow for two independent 48-well assay setups. Each aliquot of HCT-Pgp Cells is provided as a single-use assay reagent and provides sufficient volume to dispense 48 assay wells of HCT-Pgp cells into one 96-well...
| Schlagworte: | MDR1, CD243, ABCB1, EC=7.6.2.2, P-glycoprotein 1, Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1 |
| Anwendung: | P-gp substrate / inhibitor assay |
| Spezies-Reaktivität: | human |
1.676,00 €
Epidermal Growth Factor Receptor 1 (EGFR1) (Human)...
Artikelnummer: IB-IB13002
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,...
| Schlagworte: | ERBB, EGFR, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
Cyn Monkey PPARgamma Reporter Assay System
Artikelnummer: IB-C00101
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.588,00 €
Cyn Monkey PPARalpha Reporter Assay System
Artikelnummer: IB-C00111
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.588,00 €
Cyn Monkey PPARdelta Reporter Assay System
Artikelnummer: IB-C00121
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | Uncharacterized protein |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.588,00 €
Cyn Monkey FXR Reporter Assay System
Artikelnummer: IB-C00601
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | Uncharacterized protein |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.588,00 €
Dog PPARalpha Reporter Assay System
Artikelnummer: IB-D00111
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | PPARA, NR1C1, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Dog |
ab 1.588,00 €
Dog PPARdelta Reporter Assay System
Artikelnummer: IB-D00121
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | NR1C2, PPARD, PPAR-beta, PPAR-delta, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Dog |
ab 1.588,00 €
Dog FXR Reporter Assay System
Artikelnummer: IB-D00601
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | Nuclear receptor subfamily 1 group H member 4 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Dog |
ab 1.588,00 €
Human CAR2 Reporter Assay System
Artikelnummer: IB-IB00921
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | CAR, NR1I3, Orphan nuclear receptor MB67, Constitutive active response, Constitutive androstane receptor, Constitutive... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
ab 1.588,00 €