Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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PGR Reporter Assay System (pig)
Artikelnummer: IB-PG05001-32
This is an all-inclusive cell-based luciferase reporter assay kit targeting the Pig Progesterone Receptor (pgPGR). INDIGO's Pig PGR reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the pgPGR. In addition to Pig PGR Reporter Cells, this kit provides...
| Schlagworte: | PR, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | swine |
1.705,00 €
MR Reporter Assay System (rat)
Artikelnummer: IB-R00501
This is an all-inclusive cell-based luciferase reporter assay kit targeting the Rat Mineralocorticoid Receptor (rMR). INDIGO's Rat MR reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the rat MR. In addition to rat MR Reporter Cells, this kit provides...
| Schlagworte: | MR, Mlr, Nr3c2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | rat |
1.588,00 €
MR Reporter Assay System (rat)
Artikelnummer: IB-R00501-32
This is an all-inclusive cell-based luciferase reporter assay kit targeting the Rat Mineralocorticoid Receptor (rMR). INDIGO's Rat MR reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the rat MR. In addition to rat MR Reporter Cells, this kit provides...
| Schlagworte: | MR, Mlr, Nr3c2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | rat |
1.705,00 €
Live Cell Multiplex Assay Kit
Artikelnummer: IB-LCM-01
The live cell multiplex (LCM) assay provides an efficient fluorescence-based method of quantifying the relative number of live cells resident in treated wells of an assay plate. While the LCM assay may be performed as a stand-alone assay, it is has been specifically optimized to be run in multiplex with any of...
| Anwendung: | LCM assay, quantification of relative number of live cells |
ab 323,00 €
Cannabinoid Type 1 Receptor (CB1R) Reporter Assay System...
Artikelnummer: IB-IB19001
This assay uses proprietary human cells that provide constitutive expression of the Human Cannabinoid Type 1 Receptor, also referred to as CB1R. CB1R is one of the two main cannabinoid receptors identified as part of the endocannabinoid system. CB1R is highly expressed in the central nervous system, but also in...
| Schlagworte: | CB1, CNR, CB-R, CNR1, CANN6, Cannabinoid receptor 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
ab 1.588,00 €
Human RORa Reporter Assay System
Artikelnummer: IB-IB04012
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | RORA, NR1F1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, RAR-related orphan receptor A, Retinoid-related... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
4.175,00 €
Human VEGFR Reporter Assay System
Artikelnummer: IB-IB15001-32
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | FLT, FLT1, FLT-1, VEGFR-1, EC=2.7.10.1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
ab 1.588,00 €
Fibroblast Growth Factor Receptors 1 & 2 for Paracrine...
Artikelnummer: IB-IB21001-32
The family of Fibroblast Growth Factors (FGFs) comprise approximately 23 members that are related by core sequence and structure conservation, with the majority of FGFs being secreted signaling proteins. Secreted FGFs are predominantly autocrine and paracrine factors, with only three members evolved to function as...
| Schlagworte: | CD331, FLT-2, FGFR1, BFGFR, N-sam, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Human |
ab 1.588,00 €
GR (Mouse) Reporter Assay System
Artikelnummer: IB-M00201
Protein function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and...
| Schlagworte: | GR, Grl, Nr3c1, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | mouse |
ab 1.588,00 €
P-Glycoprotein / MDR1 (human) Drug Interaction Assay
Artikelnummer: IB-HPGP-48
The materials provided in the assay kit for MDR1 / Human P-Glycoprotein Drug Interaction are formatted to allow for two independent 48-well assay setups. Each aliquot of HCT-Pgp Cells is provided as a single-use assay reagent and provides sufficient volume to dispense 48 assay wells of HCT-Pgp cells into one 96-well...
| Schlagworte: | MDR1, CD243, ABCB1, EC=7.6.2.2, P-glycoprotein 1, Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1 |
| Anwendung: | P-gp substrate / inhibitor assay |
| Spezies-Reaktivität: | human |
1.676,00 €
Epidermal Growth Factor Receptor 1 (EGFR1) (Human)...
Artikelnummer: IB-IB13002
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,...
| Schlagworte: | ERBB, EGFR, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
Cyn Monkey PPARgamma Reporter Assay System
Artikelnummer: IB-C00101
The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist. This kit product is an all-inclusive assay system that includes, in addition to Reporter Cells, two optimized media for use during cell culture and (optionally) in...
| Schlagworte: | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | Cynomolgus monkey |
ab 1.588,00 €