Produkte von AdipoGen Life Sciences
AdipoGen Life Sciences verbindet Immunologie und Metabolismus. Die AdipoGen-Zentrale befindet sich in San Diego, USA mit einem Produktionslabor in der Schweiz. Hoch qualifizierte Wissenschaftler*innen entwickeln dort neue Produkte für den Life Science-Markt in den Bereichen Krebs, Immunologie, Entzündung (der Experte im Bereich Inflammasom-Forschung), Metabolisches Syndrom (Diabetes, Fettleibigkeit), Stammzellen und Neurodegeneration. Der Schwerpunkt liegt auf innovativen und fortschrittlichen ELISA-Kits. Zusätzlich zu den Antikörper- und Protein-Einrichtungen besitzt AdipoGen auch chemische Laboratorien für die Entwicklung neuer und innovativer Biochemikalien.
Mehr Informationen unter: www.adipogen.com
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EIDD-2801
Artikelnummer: AG-CR1-3733-M050
White to off-white solid. Soluble in DMSO (25mg/ml), DMF (25mg/ml) or water (2mg/ml). Chemical. CAS: 2349386-89-4. Formula: C13H19N3O7. MW: 329.3. EIDD-2801 is an orally bioavailable prodrug of the antiviral nucleoside derivative N4-hydroxycytidine (NHC, EIDD-1931). It is a nucleotide analog inhibitor of...
| Schlagworte: | beta-D-N4-Hydroxycytidine-5'-isopropyl ester, EIDD 2801 |
| Anwendung: | Antiviral |
| CAS | 2349386-89-4 |
| MW: | 329,3 D |
ab 77,00 €
Glucosylglycerol
Artikelnummer: AG-CN2-0393-G010
Slightly yellowish liquid. Soluble in water. Natural chemical product. CAS: 22160-26-5. Formula: C9H18O8. MW: 254.2. Enzymatically processed from natural succrose and glycerine. Glucosylglycerol belongs to the class of compatible solutes (osmolytes). It is a non-toxic, non-irritating protective osmolyte responsible...
| Schlagworte: | Glucosyl glycerol, Glyceryl glucoside, alpha-D-Glucopyranoside, alpha-D-Glucosylglycerol,... |
| Anwendung: | Labeling |
| CAS | 22160-26-5 |
| MW: | 254,2 D |
ab 34,00 €
Opaganib
Artikelnummer: AG-CR1-3749-M025
Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
| Schlagworte: | 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva |
| Anwendung: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
ab 99,00 €
Retatrutide . sodium salt
Artikelnummer: AG-CP3-0044-M025
Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR,...
| Schlagworte: | LY3437943, GGG Tri-agonist |
| Anwendung: | GCGR/GIPR/GLP-1R triple agonist peptide |
| MW: | 4754.4 D |
ab 66,00 €
AOH1996
Artikelnummer: AG-CR1-3553-M025
AOH1996 is an orally available and metabolically stable small molecule PCNA inhibitor, which selectively kills cancer cells, with a median concentration of about 300 nM for 50% growth inhibition. AOH1996 was not significantly toxic to non-malignant cells, even up to 10 µM. AOH1996 enhances the interaction between...
| Schlagworte: | NSC789796, N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide |
| Anwendung: | PCNA inhibitor |
| CAS | 2089314-64-5 |
| MW: | 426,5 D |
ab 83,00 €
Latrunculin A
Artikelnummer: AG-CN2-0027-C100
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Potent phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in...
| Schlagworte: | LAT-A, NSC 613011 |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421,6 D |
ab 143,00 €
Cyclosporin A (5x100mg)
Artikelnummer: AG-CN2-0079-M100
Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)) - Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B, calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells...
| Schlagworte: | Antibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193, Ramihyphin A |
| Anwendung: | Immunsuppressant |
| CAS | 59865-13-3 |
| MW: | 1202,6 D |
ab 55,00 €
MCC950 . Na
Artikelnummer: AG-CR1-3615-M001
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
| Schlagworte: | MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426,5 D |
ab 39,00 €
IL-33 (oxidation resistant) (human) (rec.) (untagged)
Artikelnummer: AG-40B-0160-C100
Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed...
| Schlagworte: | IL33, C9orf26, IL-33 (human) (C208S/C232S), Interleukin-33 (human) (C208S/C232S), IL-1F11, NF-HEV |
| Anwendung: | Cell culture, binding assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 17 kD |
ab 286,00 €
Arginase I (human) (rec.) (highly active)
Artikelnummer: AG-40T-0124-C010
Protein function: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively, the urea cycle takes place primarily in the liver...
| Schlagworte: | ARG1, Arginase-1, Type I arginase, Liver-type arginase |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 286,00 €
Flagellin (high purity)
Artikelnummer: AG-40B-0025-C010
(3 x 10µg). Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens...
| Schlagworte: | FliC |
| Anwendung: | Bioassays |
| Ursprungsart: | human, mouse |
ab 198,00 €
(-)-Viriditoxin
Artikelnummer: AG-CN2-0471-C500
Solid. Soluble in DMSO or ethanol. Antibiotic. Exhibits broad activity against Gram-positive bacteria, Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml), Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate...
| Schlagworte: | (M)-Viriditoxin, SC-28762 |
| Anwendung: | Antibiotic (Gram-positive bacteria), FtsZ inhibitor |
| CAS | 1381782-08-6 |
| MW: | 662,6 D |
154,00 €