Produkte von AdipoGen Life Sciences
AdipoGen Life Sciences verbindet Immunologie und Metabolismus. Die AdipoGen-Zentrale befindet sich in San Diego, USA mit einem Produktionslabor in der Schweiz. Hoch qualifizierte Wissenschaftler*innen entwickeln dort neue Produkte für den Life Science-Markt in den Bereichen Krebs, Immunologie, Entzündung (der Experte im Bereich Inflammasom-Forschung), Metabolisches Syndrom (Diabetes, Fettleibigkeit), Stammzellen und Neurodegeneration. Der Schwerpunkt liegt auf innovativen und fortschrittlichen ELISA-Kits. Zusätzlich zu den Antikörper- und Protein-Einrichtungen besitzt AdipoGen auch chemische Laboratorien für die Entwicklung neuer und innovativer Biochemikalien.
Mehr Informationen unter: www.adipogen.com
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Opaganib
Artikelnummer: AG-CR1-3749-M025
Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
| Schlagworte: | 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva |
| Anwendung: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
ab 99,00 €
AOH1996
Artikelnummer: AG-CR1-3553-M025
AOH1996 is an orally available and metabolically stable small molecule PCNA inhibitor, which selectively kills cancer cells, with a median concentration of about 300 nM for 50% growth inhibition. AOH1996 was not significantly toxic to non-malignant cells, even up to 10 µM. AOH1996 enhances the interaction between...
| Schlagworte: | NSC789796, N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide |
| Anwendung: | PCNA inhibitor |
| CAS | 2089314-64-5 |
| MW: | 426,5 D |
ab 83,00 €
Latrunculin A
Artikelnummer: AG-CN2-0027-C100
Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Potent phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in...
| Schlagworte: | LAT-A, NSC 613011 |
| Anwendung: | Actin polymerization inhibitor |
| CAS | 76343-93-6 |
| MW: | 421,6 D |
ab 143,00 €
Cyclosporin A (5x100mg)
Artikelnummer: AG-CN2-0079-M100
Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)) - Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B, calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells...
| Schlagworte: | Antibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193, Ramihyphin A |
| Anwendung: | Immunsuppressant |
| CAS | 59865-13-3 |
| MW: | 1202,6 D |
ab 55,00 €
MCC950 . Na
Artikelnummer: AG-CR1-3615-M001
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
| Schlagworte: | MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426,5 D |
ab 39,00 €
IL-33 (oxidation resistant) (human) (rec.) (untagged)
Artikelnummer: AG-40B-0160-C100
Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed...
| Schlagworte: | IL33, C9orf26, IL-33 (human) (C208S/C232S), Interleukin-33 (human) (C208S/C232S), IL-1F11, NF-HEV |
| Anwendung: | Cell culture, binding assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 17 kD |
ab 286,00 €
Arginase I (human) (rec.) (highly active)
Artikelnummer: AG-40T-0124-C010
Protein function: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively, the urea cycle takes place primarily in the liver...
| Schlagworte: | ARG1, Arginase-1, Type I arginase, Liver-type arginase |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 286,00 €
Flagellin (high purity)
Artikelnummer: AG-40B-0025-3010
(3 x 10µg). Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens...
| Schlagworte: | FliC |
| Anwendung: | Bioassays |
| Ursprungsart: | human, mouse |
ab 198,00 €
(-)-Viriditoxin
Artikelnummer: AG-CN2-0471-C500
Solid. Soluble in DMSO or ethanol. Antibiotic. Exhibits broad activity against Gram-positive bacteria, Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml), Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate...
| Schlagworte: | (M)-Viriditoxin, SC-28762 |
| Anwendung: | Antibiotic (Gram-positive bacteria), FtsZ inhibitor |
| CAS | 1381782-08-6 |
| MW: | 662,6 D |
154,00 €
COVID-19 Forschung
Ruxolitinib
Artikelnummer: AG-CR1-3624-M005
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
CD40L (human) (multimeric) (rec.)
Artikelnummer: AG-40B-0010-C010
Human CD40L (amino acids 116-261) is fused at the N-terminus to mouse ACRP30headless (amino acids 18-111) and a FLAG(R)-tag. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). Lyophilized. Contains PBS. MultimericCD40L is a high activity construct in which two...
| Schlagworte: | MegaCD40L(TM), Soluble (human, rec.), ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L |
| Anwendung: | Bioassays |
| Exprimiert in: | Hamster cells |
| Ursprungsart: | human |
ab 374,00 €
Trolox
Artikelnummer: AG-CR1-3639-M500
White to off-white or pale yellow solid. Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml) or methanol (5mg/ml). Slightly soluble in water (~1mg/ml) and PBS (3mg/ml). Cell permeable and water soluble derivative of vitamin E, Potent antioxidant. Efficiently prevents formation of different reactive oxygen species,...
| Schlagworte: | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, Trolox C |
| Anwendung: | Potent antioxidant |
| CAS | 53188-07-1 |
| MW: | 250,3 D |
ab 44,00 €