Produkte von AdipoGen Life Sciences
AdipoGen Life Sciences verbindet Immunologie und Metabolismus. Die AdipoGen-Zentrale befindet sich in San Diego, USA mit einem Produktionslabor in der Schweiz. Hoch qualifizierte Wissenschaftler*innen entwickeln dort neue Produkte für den Life Science-Markt in den Bereichen Krebs, Immunologie, Entzündung (der Experte im Bereich Inflammasom-Forschung), Metabolisches Syndrom (Diabetes, Fettleibigkeit), Stammzellen und Neurodegeneration. Der Schwerpunkt liegt auf innovativen und fortschrittlichen ELISA-Kits. Zusätzlich zu den Antikörper- und Protein-Einrichtungen besitzt AdipoGen auch chemische Laboratorien für die Entwicklung neuer und innovativer Biochemikalien.
Mehr Informationen unter: www.adipogen.com
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1400W . dihydrochloride
Artikelnummer: AG-CR1-0018-M005
A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd &le, 7 nM), Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki &le, 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki &le, 50 µM), Inhibits tumor growth, Increases...
| Schlagworte: | N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl |
| Anwendung: | iNOS inhibitor |
| CAS | 214358-33-5 |
| MW: | 250,3 D |
ab 44,00 €
1-Azakenpaullone
Artikelnummer: AG-CR1-0035-M005
Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM).
| Schlagworte: | 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
| Anwendung: | GSK-3beta inhibitor |
| CAS | 676596-65-9 |
| MW: | 328,2 D |
ab 83,00 €
Chelerythrine chloride
Artikelnummer: AG-CR1-0071-M005
Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase, antiplatelet, anti-inflammatory, antibacterial and antitumor compound, apoptosis inducer in cancer cells in vitro and in vivo, activates MAPK...
| Schlagworte: | NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
| Anwendung: | PKC inhibitor |
| CAS | 3895-92-9 |
| MW: | 383,8 D |
ab 33,00 €
Ruxolitinib . phosphate salt
Artikelnummer: AG-CR1-3645-M100
White to off-white solid. Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol. Water-soluble phosphate salt of Ruxolitinib, Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1?/?JAK2 inhibitor |
| CAS | 1092939-17-7 |
| MW: | 404,4 D |
ab 44,00 €
Kirromycin
Artikelnummer: BVT-0157-M001
Antibiotic. Member of the elfermycin group. Antibacterial. Protein biosynthesis inhibitor. Specifically interacts with the bacterial elongation factor EF-Tu and prevents the release of EF-Tu from the bacterial ribosome after GTP hydrolysis, in the absence of ribosomes it induces EF-Tu-dependent hydrolysis of GTP....
| Schlagworte: | Mocimycin, Delvomycin, MYC 8003, NSC 316094 |
| Anwendung: | Antibiotic, Protein biosynthesis inhibitor |
| CAS | 50935-71-2 |
| MW: | 796,9 D |
240,00 €
CTRP5 (human, rec.) (His)
Artikelnummer: AG-40A-0142-C050
Human CTRP5 (amino acids 16-243) is fused at the N-terminus to a His-tag. Lyophilized from a 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. CTRP5 (C1qTNF-related protein 5, C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated...
| Schlagworte: | Complement C1q Tumor Necrosis Factor-related Protein 5, C1QTNF5 |
| Anwendung: | Bioassays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 26 kD |
ab 237,00 €
Ingenol-3-angelate
Artikelnummer: AG-CN2-0012-M001
Specific protein kinase C (PKC) activator, Selective activator of PKC isoforms, like PKCtheta in T cells, Antiproliferative and proapoptotic (necrotic), Immunostimulant, Chemotherapeutic, Anticancer compound, Efficacious agent against actinic kerastosis, Antileukemic. Isolated from Euphorbia peplus L.
| Schlagworte: | PEP005, I3A |
| Anwendung: | Protein kinase C (PKC) activator |
| CAS | 75567-37-2 |
| MW: | 430,5 D |
ab 132,00 €
Cyclopamine
Artikelnummer: AG-CN2-0028-M005
A steroidal alkaloid isolated from the desert plant Veratrum californicum with both teratogenic and antitumor activities. It inhibits hedgehog/smoothened signaling.
| Schlagworte: | 11-Deoxyjervine, 11-Deoxojervine, HSDB 3505 |
| Anwendung: | Biochemical studies |
| CAS | 4449-51-8 |
| MW: | 411,6 kD |
ab 36,00 €
Lovastatin
Artikelnummer: AG-CN2-0051-M025
Statin compound, potent competitive HMG-CoA reductase inhibitor, anti-hypercholesterolemic agent, Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids, inhibits the isoprenylation of Ras and Rho family GTPases, causes...
| Schlagworte: | Mevilonin, MK-803, 6-alpha-Methylcompactin, BRN 3631990 |
| Anwendung: | NF-kappaB activation inhibitor |
| CAS | 75330-75-5 |
| MW: | 404,6 D |
ab 22,00 €
Citrinin
Artikelnummer: AG-CN2-0101-M025
Antibiotic, antiprotozoal. Antimicrobial, cytotoxic and genotoxic in various mammalian cells, mitochondrial permeability transition pore (MPTP) activator, apoptosis inducer, ERK and JNK signaling pathways activator, nephrotoxic mycotoxin, suppresses NO and iNOS expression via inhibition of the JAK/STAT-1aplha and...
| Schlagworte: | NSC 186, BRN 0088597, Antimycin |
| Anwendung: | Apoptosis Inducer |
| CAS | 518-75-2 |
| MW: | 250,3 D |
ab 44,00 €
KN-93 (water soluble)
Artikelnummer: AG-CR1-0065-M001
Selective Ca2 dependent protein kinase II inhibitor, Insulin release inhibitor, Acid secretion inhibitor, G1 cell cycle arrest inducer, Apoptosis inducer, Ion channel inhibitor, ROS inducer, Androgen receptor inhibitor.
| Schlagworte: | KN-93 . H3PO4, 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . H3PO4 |
| Anwendung: | Ca2 dependent protein kinase II inhibitor |
| MW: | 501 D |
ab 33,00 €
Amlexanox
Artikelnummer: AG-CR1-3579-M010
Soluble in DMSO or dimethylformamide. Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to the...
| Schlagworte: | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, AA 673, Amoxanox, CHX 3674 |
| Anwendung: | TBK1 / IKKE inhibitor |
| CAS | 68302-57-8 |
| MW: | 298,3 D |
ab 22,00 €